Effects of Bombesin and Bombesin-Like Peptides on Gastrointestinal Myoelectric Activity
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چکیده
منابع مشابه
Effect of cerebroventricular perfusion of bombesin on gastrointestinal myoelectric activity.
The effect of intracerebroventricular (ICV) perfusion of bombesin (BBS) on the interdigestive migrating myoelectric complex (MMC) actvity was examined in conscious dogs with electrodes implanted on the stomach and small intestine. Cannulas and a catheter were chronically positioned in the lateral and fourth cerebral ventricles, respectively. ICV perfusion of BBS, which failed to increase plasma...
متن کاملPotentiating Endogenous Bombesin-like Peptides
Bombesin-like peptides (BLPs) are mitogens for bronchial epithelial cells and small cell lung carcinomas, and increase fetal lung growth and maturation in utero and in organ cultures. BLPs are hydrolyzed by the enzyme CD10/neutral endopeptidase 24.11 (CD10/NEP) which is expressed in bronchial epithelium and functions to inhibit BLP-mediated growth of small cell lung carcinomas. To determine whe...
متن کاملOccurrence and polymorphism of bombesin-like peptides in the gastrointestinal tract of birds and mammals.
The gastrointestinal tract of mammals and birds, especially stomach and upper small intestine, contains bombesin-like peptides. This has been unequivocally demonstrated by radioimmunoassay and bioassay. Concentrations of bombesin-like activity may range from a few ng to 500-600 ng per g fresh tissue. Last values refer to the chicken proventriculus, which has been the object of a more thorough i...
متن کاملDevelopment and function of bombesin-like peptides and their receptors.
Amphibian bombesin and its related peptides consist a family of neuropeptides in many vertebrate species. Bombesin and two major bombesin-like peptide in mammals, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been shown to elicit various physiological effects. These include inhibition of feeding, smooth muscle contraction, exocrine and endocrine secretions, thermoregulation, bloo...
متن کاملBombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia.
RATIONALE The incidence of bronchopulmonary dysplasia (BPD), a chronic lung disease of newborns, is paradoxically rising despite medical advances. We demonstrated elevated bombesin-like peptide levels in infants that later developed BPD. In the 140-day hyperoxic baboon model of BPD, anti-bombesin antibody 2A11 abrogated lung injury. OBJECTIVES To test the hypothesis that bombesin-like peptide...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1975
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(75)80238-1